Hayashi Lab.

Publications

研究業績

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査読論文

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2026

  • Hayashi K, Miki K, Fukushima Y, Iwai M, Shiro Y, Tetsunaga T, Takasusuki T, Hosoi M, Yukioka M, Okada S. Personality traits have an effect on pain-related psychological variables in patients with chronic low back pain. PLoS One. 2026; 21(7):e0354827.
    PubMed
  • Kato R, Hayashi K, Okada Y, Okura R, Niida F, Miyata J, Sakitani N, Sawada Y, Ito A. Passive Oscillatory Body Motion Attenuates Pain-Related Behaviors and Increases β-Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study. Brain Behav. 2026; 16(7):e71614.
    PubMed
  • Janowski AJ, Hayashi K, Plumb AN, Lesnak JB, Smith AF, Rasmussen L, Gross E, Post AA, Berardi G, Klein ME, Brown R, Vignes H, Taylor EB, Nackley AG, Sluka KA. Behavioral and molecular characterization of fatigue-like manifestations triggered by acute restraint stress and LPS or saline. Sci Rep. 2026.
    PubMed
  • Masuda S, Nagai-Tanima M, Kawaguchi A, Hayashi K, Aoyama T. Effects of controlling anterior tibial translation preserve sensory-motor function and mechanoreceptor morphology following anterior cruciate ligament injury in rats. Sci Rep. 2026; 16(1):27897.
    PubMed
  • Yanagisawa T, Furuya N, Tatematsu N, Hayashi K. Effectiveness of comprehensive interventions including exercise and exercise-only interventions on postoperative ileus and recovery of intestinal function in patients with colorectal cancer: a systematic review and meta-analysis. Support Care Cancer. 2026; 34(6):540.
    PubMed
  • Yanagisawa T, Okamoto T, Hayashi K. Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis. Support Care Cancer. 2026; 34(4):348.
    PubMed

2025

  • Nohara D, Nagai-Tanima M, Masuda S, Toyota M, Nakahara R, Hayashi K, Aoyama T. Effect of Stretching on Skeletal Muscle Fibrosis in Sarcopenia. JCSM Commun. 2025; 8(2):e70021.
    PubMed
  • Hayashi K, Miki K, Ueno H, Sekiguchi M, Arai YC, Nikaido T, Shiga Y, Inoue M, Kataoka H, Kawarai Y, Kimura Y, Shimizu K, Shimo K, Shiro Y, Tanaka K, Tanaka S, Hirakawa Y, Miura K, Yukioka M. Randomized open-label non-inferiority trial of paracetamol or celecoxib for patients with chronic low back pain. Sci Rep. 2025; 16(1):1577.
    PubMed
  • Hayashi K, Lesnak JB, Plumb AN, Janowski AJ, Rasmussen LA, Vignes H, Flanagan R, Berardi G, Paradee WJ, Sluka KA. Acid-sensing ion channel 3 in macrophages, but not sensory neurons, mediates development of activity-induced muscle pain. Brain Behav Immun. 2025; 130:106122.
    PubMed
  • Yanagisawa T, Tatematsu N, Hayashi K. Impact of home-based preoperative physical activity on postoperative complications in patients undergoing oncologic surgery: a systematic review and meta-analysis. Discov Oncol. 2025; 16(1):1571.
    PubMed
  • Janowski AJ, Berardi G, Hayashi K, Plumb AN, Lesnak JB, Khataei T, Martin B, Benson CJ, Sluka KA. The influence of sex on activity in voluntary wheel running, forced treadmill running, and open field testing in mice. Physiol Rep. 2025; 13(4):e70246.
    PubMed
  • Hayashi K, Miki K, Shiro Y, Tetsunaga T, Takasusuki T, Hosoi M, Yukioka M. Utilization of telemedicine in conjunction with wearable devices for patients with chronic musculoskeletal pain: a randomized controlled clinical trial. Sci Rep. 2025; 15:1396.
    PubMed

2024

  • Plumb AN, Hayashi K, Janowski A, Smith AF, Rasmussen L, Sluka KA, Lesnak JB. Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain. Pain Rep. 2024; 9(6):e1207.
    PubMed
  • Hayashi K, Lesnak JB, Plumb AN, Janowski A, Smith A, Sluka KA. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. Brain Behav Immun. 2024; 120:471–487.
    PubMed

2023

  • Hayashi K, Shi K, Miki K, Yukioka M, Shibata M, Yoshikawa H. Discordance of global assessment between the patients and physicians predicts 9-year pain-related outcomes in rheumatoid arthritis patients. Front Med. 2023; 10:1189748.
    PubMed
  • Hayashi K, Miki K, Ikemoto T, Ushida T, Shibata M. Predictors of high-cost patients with acute whiplash-associated disorder in Japan. PLoS One. 2023; 18(6):e0287676.
    PubMed
  • Hayashi K, Janowski A, Lesnak JB, Sluka KA. Preoperative exercise has an impact on postoperative pain within the first 6 months after surgery: A Systematic Review and Meta-Analysis of randomized controlled trials across various types of surgeries. Phys Ther. 2023; 103(3):pzac169.
    PubMed
  • Lesnak JB, Hayashi K, Plumb AN, Janowski AJ, Chimenti MS, Sluka KA. The impact of sex and physical activity on the local immune response to muscle pain. Brain Behav Immun. 2023; 111:4–20.
    PubMed
  • Plumb AN, Lesnak JB, Berardi G, Hayashi K, Janowski A, Smith A, Bailey D, Kerkman C, Kienenberger Z, Martin B, Patterson E, Van Roekel H, Vance C, Sluka KA. Standing on the shoulders of bias: lack of transparency and reporting of critical rigor characteristics in pain research. Pain. 2023; 164(8):1775–1782.
    PubMed
  • Hayashi K, Lesnak JB, Plumb AN, Rasmussen LA, Sluka KA. P2X7-NLRP3-Caspase-1 signaling mediates activity-induced muscle pain in male but not female mice. Pain. 2023; 164(8):1860–1873.
    PubMed

2022

  • Haider S, Janowski A, Lesnak JB, Hayashi K, Dailey D, Chimenti R, Frey-Law L, Sluka KA, Berardi G. A comparison of pain, fatigue, and function between post-COVID-19 condition, fibromyalgia, and chronic fatigue syndrome: a survey study. Pain. 2022; 164(2):385–401.
    PubMed
  • Hayashi K, Ikemoto T, Shiro Y, Arai YC, Marcuzzi A, Costa D, Wrigley P. A systematic review of the variations in Pain Catastrophizing Scale reference scores based on language version and country in patients with chronic primary pain. Pain Ther. 2022; 11(3):753–769.
    PubMed

2021

  • Hayashi K, Miki K, Kajiyama H, Ikemoto T, Yukioka M Impact of Non-Steroidal Anti-Inflammatory Drugs administration for 12 months on renal function. Frontiers in Pain Research. 2021; 2:644391.
    PubMed
  • Hayashi K, Miki K, Hayashi N, Hashimoto R, Yukioka M. Weather sensitivity associated with quality of life in patients with fibromyalgia. BMC Rheumatology. 2021; 5(1):14.
    PubMed
  • Shiro Y, Nagai S, Hayashi K, Aono S, Nishihara M, Ushida T. Changes in visual attentional behavior in complex regional pain syndrome: A preliminary study. PLoS One. 2021; 16(2):e0247064.
    PubMed

2020

  • Ikemoto T, Ueno T, Arai YC, Wakao N, Hirasawa A, Hayashi K, Deie M. Open-label placebo trial among Japanese patients with chronic low back pain. Pain Res Manag. 2020; 2020:6636979.
    PubMed
  • Ikemoto T, Shiro Y, Ikemoto K, Hayashi K, Arai YC, Deie M, Beeston L, Wood B, Nicholas M. Feasibility of Imported Self-Management Program for Elderly People with Chronic Pain: A Single-Arm Confirmatory Trial. Pain Ther. 2020; 9(2):583–599.
    PubMed
  • Hayashi K, Fukuyasu-Matsuo S, Inoue T, Fujiwara M, Asai Y, Iwata M, Suzuki S. Effects of Cyclic Stretching Exercise on Long-Lasting Hyperalgesia, Joint Contracture, and Muscle Injury Following Cast Immobilization in Rats. Physiol Res. 2020; 69(5):861–870.
    PubMed
  • Ikemoto T, Hayashi K, Shiro Y, Arai YC, Marcuzzi A, Costa D, Wrigley P. A systematic review of cross-cultural validation of the pain catastrophizing scale. Eur J Pain. 2020; 24(7):1228–1241.
    PubMed
  • Hayashi K, Aono S, Fujiwara M, Shiro Y, Ushida T Difference in eye movements during gait analysis between professionals and trainees. PLoS One. 2020; 15(4):e0232246.
    PubMed
  • Hayashi K, Miki K, Ikemoto T, Ushida T, Shibata M. Associations between the Injustice Experience Questionnaire and treatment term in patients with acute Whiplash-associated disorder in Japan: Comparison with Canadian data. PLoS One. 2020; 15(4):e0231077.
    PubMed

2019

  • Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation. Crit Care Explor. 2019; 1(12):e0066.
    PubMed
  • Hayashi K, Aono S, Shiro Y, Ushida T. Effects of Virtual Reality-Based Exercise Imagery on Pain in Healthy Individuals. Biomed Res Int. 2019; 2019:5021914.
    PubMed
  • Hayashi K, Miki K, Ikemoto T, Ushida T, Shibata M. Factors influencing outcomes among patients with whiplash-associated disorder: A population-based study in Japan. PLoS One. 2019; 14(5):e0216857.
    PubMed
  • Ikemoto T, Hayashi K, Arai YC, Nishihara M, Inoue S, Inoue M, Shiro Y, Ushida T. The Relationship Between Musculoskeletal Pain and Picky Eating: The Role of Negative Self-Labeling. Pain Ther. 2019; 8(1):101–110.
    PubMed
  • Hayashi K, Morishima T, Ikemoto T, Miyagawa H, Okamoto T, Ushida T, Deie M. Pain Catastrophizing Is Independently Associated with Quality of Life in Patients with Severe Hip Osteoarthritis. Pain Med. 2019; 20(11):2220–2227.
    PubMed

2018

  • Hayashi K, Kako M, Suzuki K, Takagi Y, Terai C, Yasuda S, Kadono I, Seki T, Hiraiwa H, Ushida T, Nishida Y. Impact of variation in physical activity after total joint replacement. J Pain Res. 2018; 11:2399–2406.
    PubMed
  • Shiro Y, Ikemoto T, Hayashi K, Arai YC, Deie M, Ueno T. Does monetary reward operantly enhance pain sensitivity over time? An experiment in healthy individuals. J Pain Res. 2018; 11:2161–2167.
    PubMed
  • Hayashi K, Ikemoto T, Ueno T, Arai YP, Shimo K, Nishihara M, Suzuki S, Ushida T. Discordant Relationship Between Evaluation of Facial Expression and Subjective Pain Rating Due to the Low Pain Magnitude. Basic Clin Neurosci. 2018; 9(1):43–50.
    PubMed
  • Hayashi K, Oshima H, Shimizu M, Kobayashi K, Matsui S, Nishida Y, Usui A. Preoperative 6-Minute Walk Distance Is Associated With Postoperative Cognitive Dysfunction. Ann Thorac Surg. 2018; 106(2):505–512.
    PubMed
  • Miki K, Ikemoto T, Hayashi K, Arai YC, Sekiguchi M, Shi K, Ushida T. Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. J Orthop Sci. 2018; 23(3):483–487.
    PubMed
  • Hayashi K, Kobayashi K, Shimizu M, Tsuchikawa Y, Kodama A, Komori K, Nishida Y. Self-efficacy is an independent predictor for postoperative six-minute walk distance after elective open repair of abdominal aortic aneurysm. Disabil Rehabil. 2018; 40(10):1114–1118.
    PubMed
  • Hayashi K, Fukumoto K, Yokoi K, Nagaya M, Inoue T, Ito S, Nakajima H, Hattori K, Kadono I, Nishida Y. Post-operative delayed ambulation after thymectomy is associated withpre-operative six-minute walk distance. Disabil Rehabil. 2018; 40(16):1900–1905.
    PubMed

2017

  • Fujiwara M, Iwata M, Inoue T, Aizawa Y, Yoshito N, Hayashi K, Suzuki S. Decreased grip strength, muscle pain, and atrophy occur in rats following long-term exposure to excessive repetitive motion. FEBS Open Bio. 2017; 7(11):1737–1749.
    PubMed
  • Shiro Y, Ikemoto T, Terasawa Y, Arai YP, Hayashi K, Ushida T, Matsubara T. Physical Activity May Be Associated with Conditioned Pain Modulation in Women but Not Men among Healthy Individuals. Pain Res Manag. 2017; 2017:9059140.
    PubMed
  • Shiro Y, Arai YC, Ikemoto T, Hayashi K. Stool consistency is significantly associated with pain perception. PLoS One. 2017; 12(8):e0182859.
    PubMed
  • Hayashi K, Kako M, Suzuki K, Hattori K, Fukuyasu S, Sato K, Kadono I, Sakai T, Hasegawa Y, Nishida Y. Associations among pain catastrophizing, muscle strength, and physical performance after total knee and hip arthroplasty. World J Orthop. 2017; 8(4):336–341.
    PubMed
  • Hayashi K, Inoue T, Nagaya M, Ito S, Nakajima H, Hattori K, Kadono I, Yokoi K, Nishida Y. Combination Treatment of Perioperative Rehabilitation and Psychoeducation Undergoing Thoracic Surgery. Case Rep Med. 2017; 2017:4743952.
    PubMed
  • Hayashi K, Yokoyama Y, Nakajima H, Nagino M, Inoue T, Nagaya M, Hattori K, Kadono I, Ito S, Nishida Y. Preoperative 6-minute walk distance accurately predicts postoperative complications after operations for hepato-pancreato-biliary cancer. Surgery. 2017; 161(2):525–532.
    PubMed

2016

  • Hayashi K, Nishiwaki K, Kako M, Suzuki K, Hattori K, Sato K, Kadono I, Nishida Y. Combination of Continuous Epidural Block and Rehabilitation in a Case of Complex Regional Pain Syndrome. J Nippon Med Sch. 2016; 83(6):262–267.
    PubMed
  • Hayashi K, Ikemoto T, Ueno T, Arai YC, Shimo K, Nishihara M, Suzuki S, Ushida T. Higher pain rating results in lower variability of somatosensory cortex activation by painful mechanical stimuli: An fMRI study. Clin Neurophysiol. 2016; 127(4):1923–1928.
    PubMed
  • Hayashi K, Kako M, Suzuki K, Hattori K, Fukuyasu S, Sato K, Kadono I, Sakai T, Hasegawa Y, Nishida Y. Gait Speeds Associated with Anxiety Responses to Pain in Osteoarthritis Patients. Pain Med. 2016; 17(3):606–613.
    PubMed
  • Hayashi K, Hirashiki A, Kodama A, Kobayashi K, Yasukawa Y, Shimizu M, Kondo T, Komori K, Murohara T. Impact of preoperative regular physical activity on postoperative course after open abdominal aortic aneurysm surgery. Heart Vessels. 2016; 31(4):578–583.
    PubMed

2015

  • Hayashi K, Arai YC, Ikemoto T, Nishihara M, Suzuki S, Hirakawa T, Matsuo S, Kobayashi M, Haruta M, Kawabata Y, Togo H, Noguchi T, Hase T, Hatano G, Ushida T. Predictive factors for the outcome of multidisciplinary treatments in chronic low back pain at the first multidisciplinary pain center of Japan. J Phys Ther Sci. 2015; 27(9):2901–2905.
    PubMed
  • Hayashi K, Ikemoto T, Ueno T, Arai YC, Shimo K, Nishihara M, Suzuki S, Ushida T. Regional differences of repeatability on visual analogue scale with experimental mechanical pain stimuli. Neurosci Lett. 2015; 585:67–71.
    PubMed
  • Hayashi K, Arai YC, Morimoto A, Aono S, Yoshimoto T, Nishihara M, Osuga T, Inoue S, Ushida T. Associations between pain drawing and psychological characteristics of different body region pains. Pain Pract. 2015; 15(4):300–307.
    PubMed

2014

  • Makino I, Arai YC, Aono S, Hayashi K, Morimoto A, Nishihara M, Ikemoto T, Inoue S, Mizutani M, Matsubara T, Ushida T. The effects of exercise therapy for the improvement of jaw movement and psychological intervention to reduce parafunctional activities on chronic pain in the craniocervical region. Pain Pract. 2014; 14(5):413–418.
    PubMed