Research

Research Overview

Our long-term goal is to improve the management of pain, dyspnea, fatigue, and other symptoms through basic and human research.

Topics

Neurobiology of pain

Neurobiology of pain

There is a need to better underlying the mechanisms of pain. We are currently examining the contribution of neuro-immune interaction in the development of musculoskeletal pain and chronification.

Hayashi K. Brain Behav Immun. 2024,
and other publications.
Individual variability in pain sensitivity

Individual variability in sensory systems

Individual differences in sensory experiences are important in the treatment. We are currently examining why women appear to have a higher risk of some pain conditions, and the mechanisms that contribute to the construction of individual differences.

Janowski AJ. Physiol Rep. 2025,
and other publications.
Effectiveness of exercise therapy

Effectiveness of exercise therapy

Regular physical activity and exercise is an effective treatment for some symptoms. We are currently examining the underlying peripheral and central mechanisms for how exercise can improve symptoms, and developing better therapeutic approaches.

Yanagisawa T. Support Care Cancer. 2026,
and other publications.
Developing a clinical prediction rule for physical therapy

Developing a clinical prediction rule for physical therapy

A clinical prediction rule is a set of variables used to assist in the process of clinical prediction. We are currently examining a prospective clinical prediction rule for physical therapy in patients with cardiopulmonary/internal disease, cancer, orthopedic diseases, and others.

Hayashi K. PLoS One. 2023,
and other publications.